Speaker
Description
ABSTRACT
Objective: The main purpose of this study was to develop an oral liquid preparation (floating oral in situ gel system) by using nontoxic, biocompatible and biodegradable gel forming ingredients for delivery of Montelukast Sodium that increase the convenience of administration and produce a correct therapeutic amount of drug, in addition to produce a sustained release of drug by increasing the residence time resulting in a controlled drug delivery in GIT.
Methods: Montelukast Sodium in situ gels at different concentration (w/v) of Gellan gum, sodium alginate and Pectin were prepared and characterized in the terms of pH Measurement, drug content, In vitro Floating Study, In-vitro gelation study, viscosity and in vitro release study.
Results: The drug content was found to be in the accepted range for all the formulations indicating uniform distribution of drug. The in vitro floating test revealed the ability of all formulae to maintain buoyant for more than 12 h. The viscosity of the formulations in solution increased with increasing concentrations of ion sensitive gel forming ingredients (Gellan gum, sodium alginate and pectin) and the concentration of gas generating agent (CaCO3). In vitro release study showed that the release of Montelukast Sodium from these gels was characterized by an initial phase of high release (burst effect) and translated to the second phase of moderate release.
Conclusion: The prepared floating in situ gel of appears to be a promising as a stomach specific delivery system of montelukast sodium for better treatment.
Keywords: Oral sustained drug delivery, Floating In situ gel, Montelukast Sodium.
Field/discipline | Pharmaceutics |
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Intend to be published in the conference journal (IJPS)? | Yes |
Has the manuscript been published? | Not published |