Speaker
Description
Lack of safe available nonresistant treatment for visceral leishmaniasis (Kala-azar) limiting the complete cure with toxic side effects or less effective leading to disease relapse light the way to the search for imperative drugs from natural resources with several herbal extracts have been shown to have antileishmanial activity. In the present study, the comparative in vitro anti-leishmania activity of various fractions of Osteospermum ecklonis aerial parts fractions have been evaluated. Extracts were prepared through maceration and Soxhlet apparatus using 85% methanol and fractionation was done by separating the active constituents according to the differences in their polarities using petroleum ether, chloroform, ethyl acetate and n-butanol respectively. Among those fractions petroleum ether as well as n-butanol fractions were chosen for effective inhibition of Leishmania donovani, the results prove with no doubt that the petroleum ether fraction of the maceration aerial parts with a concentration of 2.5 mg/ml had better antileishmanial activity than other concentrations of tested samples and the result coincided with the anti-leishmaniasis activity of official treatment (pentostam®) which can be attributed to the terpene nature of the materials used to be existed in such fraction. This observation emphasizes the new road to step in for extended studies in relation to the conventional herbal medicines for better and safe alternatives to available synthetic chemical drugs.
| Intend to be published in the conference journal (IJPS)? | Yes |
|---|---|
| Has the manuscript been published? | Not published |
| Field/discipline | pharmacognosy |
