Speakers
Description
This work illustrates the synthesis of new isatin Schiff base
compounds, to acquire and study the new pharmacological effects of
them. First, isatin and its analogs 5- fluoroisatin and 5- methoxyisatin
reacted to obtain N- benzylated derivatives. This is by isatin reaction
with benzyl halide and reflux stirring to get N-benzylated derivatives;
compounds 2(a-c). Second, to get Schiff bases compounds 3(a-c) and
4(a-c),the N-benzylated derivatives; compounds 2(a-c) react by reflux
stirring with two different amines (sulphanilamide and 4-(methyl
sulphonyl) aniline) using glacial acetic acid as a catalyst in ethanol will
achieve it.
All compounds characterized by using (FT-IR and 1HNMR) and
this is acceptable with their chemical structures.
The synthesized Schiff bases examined for in vitro anti-microbial
activity using Gram-positive species of bacteria (Staphylococcus
aureus, Streptococcus pyogenes, and Enterococcus faecalis) using
Amoxicillin as a standard drug, while for three Gram-negative species
of bacteria (Klebsiella pneumoniae, Escherichia coli, and
Pseudomonas aeruginosa) use Ciprofloxacin as a standard drug.
Finally, as a fungus; Candida albicans, Fluconazole used as an
antifungal drug.
At the two concentrations used (1.6 and 5 mg / mL), all Schiff
bases display no antifungal activity and Klebsiella pneumoniae
bacteria, moreover all compounds show no activity at the concentration
(1.6 mg/mL), while most compounds show moderate antibacterial
activity at concentration 5 mg/mL towards most bacteria. However,
compounds 3b and 3c exhibit no activity toward all bacteria that
examined.
| Field/discipline | Pharmaceutical Chemistry |
|---|---|
| Has the manuscript been published? | Published |
| Intend to be published in the conference journal (IJPS)? | No |
