(Current Challenges and Updates in Pharmacy Education and Research)

Correlation of staging and risk factors with cardiovascular autonomic neuropathy in patients with type II diabetes mellitus

Not scheduled

5m

كلية الصيدلة

poster Track Two (August 25th, 8-10 PM)

Speaker

Mohened Al-Kaisey (Baghdad college of medical sciences)

Description

The impairment of cardiovascular autonomic control among the underdiagnosed complication
of diabetes mellitus (DM) with a high prevalence rate of up to 60% in type 2 DM (T2DM). Cardiac
autonomic neuropathy (CAN) is an independent risk factor for cardiovascular mortality, arrhythmia,
silent ischemia, any major cardiovascular event, and heart failure. We aimed to evaluate
cardiovascular autonomic activity by different physiological maneuvers, study risk factors for diabetic
CAN including age, gender, duration of diabetes, body mass index (BMI), and glycemic control, and
correlate CAN stage with risk factors. One hundred and forty-two T2DM patients consisted of 62 males
and 80 females and 100 volunteers as a control sample. Cardiac autonomic functions were assessed
by Ewing’s tests. Glycated hemoglobin (HbA1c), body weight, height, body mass index (BMI), and
waist-hip ratio (WHR) were also measured. Cardiovascular autonomic functions and Ewing scores were
significantly different in people with diabetes when compared with control healthy subjects. Ewings
test values and Ewing scores were significantly different between diabetics with and without CAN
and within patients with different CAN staging. People with diabetes with CAN have a significantly
longer duration of disease when compared to those without CAN. A strong association has been
found between CAN severity and patient age, duration of disease, HbA1c severity, and the WHR
(P < 0.001) but not with BMI. The duration of disease and HbA1c level appear to be associated with the
development of CAN (P = 0.001 and P = 0.008, respectively). The poorer glycemic control and the longer
the duration of the disease, the higher the prevalence of CAN in T2DM. Age, duration of disease,
WHR, and HbA1c are well correlated with the severity of CAN. Parasympathetic impairment is more
sensitive to the detection of autonomic dysfunctions than do sympathetic impairment.