Speaker
Description
Experimental evidence suggests that safranal, an organic compound, isolated from saffron (Crocus sativus) had anti-inflammatory and antioxidant effects. In the present study, we investigated the protective effect of safranal on the lipopolysaccharide LPS induced acute lung injury ALI model. Sixty albino BALB/c male (20-30g) mice were divided into five groups: control group (vehicle administration), an induction group received vehicle for 7 consecutive days then LPS 5mg/kg as a single dose on day 7.two treatment groups received safranal IP (300,150 mg/kg) respectively for 7 consecutive days then LPS 5mg/kg as a single dose administrated at day seven, and the final group received safranal 300mg/kg without LPS stimulation. The experiment ended on day eight, bronchoalveolar lavage fluid, blood and lung tissue were collected .total and differential cell count, lung wet/dry ratio, tissue TNF-α, IL-33, and serum IgE levels were significantly (p < 0.05) increased after LPS administration and the antioxidant GSH levels were significantly decreased. In contrast, safranal 300 mg/kg could ameliorate ALI by decreasing the levels of (total and differential cell count, wet-dry ratio, and IgE) and the treatment with safranal 150 mg/kg showed a significant reduction in (differential cell count, TNF-α, IL-33, and IgE). And a significant increase in GSH levels. These results suggest that safranal has a protective effect on LPS induced ALI in mice likely through the anti-inflammatory and antioxidant effect.
| Has the manuscript been published? | Accepted for published |
|---|---|
| Journal name | International Journal of drug Delivery Technology |
