(Current Challenges and Updates in Pharmacy Education and Research)

Inspecting the Possible Effect of CoQ10 Supplement on Tumor Marker CA 15-3 in a sample of Iraqi Women with Breast Cancer.

Not scheduled

5m

كلية الصيدلة

poster Track Two (August 25th, 8-10 PM)

Speaker

Mrs ZAYNEB AHMED MOHAMMED AL-HASHEMI (University of Baghdad College of Pharmacy )

Description

Abstract
Background: Breast cancer is a threatening disease for women's health globally. CA 15-3 is a tumor marker used in conjugation with other tests and procedures in monitoring treatment response, disease recurrence, and cancer metastasis. Many biological substances have been recognized to play a beneficial role in reducing oxidative stress and enhancing antioxidant states for patients with breast cancer. Coenzyme Q10 is a naturally occurring ubiquinone with antioxidant properties and takes a crucial part in cellular respiration.
Objectives: This project was designed to examine the possible effect of two-months supplementation with Coenzyme Q10 on serum level of tumor marker CA 15-3 in women who had newly diagnosed with breast cancer in Iraq.
Materials and Methods: 71 postoperative women who were newly histologically diagnosed with breast cancer stages (I, II, III) before starting chemotherapy distributed randomly into two groups: (group I) those supplemented with Coenzyme Q10 beside the chemotherapy AC (Adriamycin plus Cyclophosphamide), while (group II) undergoing the (AC) chemotherapy regimen only.
Results and Conclusion: At the end of the study, the serum level of Coenzyme Q10 increased dramatically after the supplementation with Coenzyme Q10. A non-significant reduction in serum levels of CA 15-3 was observed in both groups.
Keywords: breast cancer, CA 15-3, CoQ10, AC