Abstract
Aim:
➢ In Silico Gyrase Binding Evaluation: Assess the binding of each compound to the GyrA–DNA complex through molecular docking simulations. Compare the docking results of our novel inhibitors with levofloxacin (a reference fluoroquinolone) docked in the same system.
➢ Synthesis of New Gyrase Inhibitors: Prepare a benzoxazole–thioether derivatives via a concise route
➢ Structural Characterization: Fully characterize all synthesized compounds (FTIR, NMR) to confirm their structures and purity.
➢ Biological Activity Testing: Evaluate the antibacterial efficacy of the synthesized compounds in vitro. determining MICs of lead compounds against representative strains (E. coli, S. aureus; optional M. tuberculosis) with levofloxacin as benchmark.
| Intend to be published in the IJPS ? | NO |
|---|---|
| Has the manuscript been published | published |
