Abstract
Abstract
Nephrolithiasis is a common renal disorder characterized by the formation of kidney stones, for which medicinal plants have traditionally been used. The present study aimed to evaluate the anti-nephrolithiatic potential of five traditionally used medicinal plants: Paronychia argentea, Teucrium polium, Alhagi maurorum, Varthemia iphionoides, and Crataegus aronia. Aqueous extracts were evaluated in ethylene glycol-induced nephrolithiasis in Wistar rats. Urinary parameters, including volume, pH, uric acid, phosphorus, calcium, oxalate, and urea, as well as serum biochemical parameters and renal histopathology, were assessed.
The aqueous extracts significantly increased urine volume and urinary pH, particularly those of T. polium, A. maurorum, C. aronia, and V. iphionoides. Several extracts significantly reduced urinary uric acid, calcium, oxalate, and phosphorus levels and improved serum biochemical parameters, including calcium, BUN, magnesium, and creatinine. Histopathological findings suggested that V. iphionoides and A. maurorum may help reduce renal tissue damage and crystal retention. Overall, the findings provide experimental support for the traditional use of these medicinal plants in the prevention and management of nephrolithiasis.
| Intend to be published in the IJPS ? | NO |
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| Has the manuscript been published | published |
