Speaker
Abstract
Atherosclerosis is multi-factorial cardiovascular disease associated with metabolic disorders, inflammation, and heart damage. The objective of this study was to compare selected anthropometry and biochemistry parameters between patients with atherosclerosis and healthy control and to determine differences before and after coronary angiography. This is a case-control study that included 80 participants, with 40 patients having atherosclerosis and 40 healthy controls. Anthropometric measurements and biochemical values (glucose, lipid parameters, BNP, CRP, troponin, AST, urea, and creatinine) were analyzed. Patients were assessed before the procedure as well as afterwards. For statistical analysis, ANOVA followed by Tukey's post hoc test was used with p < 0.05 indicating a significant difference. The patients were significantly overweight (83.09 ± 8.96 vs. 76.59 ± 9.10 kg, P = 0.001) and had a higher BMI (27.95 ± 2.52 vs. 25.99 ± 2.48 kg/m², P = 0.002) than the control subjects. BNP levels differed significantly between the control group and pre-catheterization group (mean difference −113.32, P < 0.001) as well as between the pre- and post-catheterization groups (29.37, P = 0.003). Furthermore, CRP levels were significantly different in all groups (P < 0.001). Troponin levels showed a difference between control and pre-catheterization (−1.75, P < 0.001) and pre- and post-catheterization (1.47, P < 0.001) groups. There were also significant differences in cholesterol, triglycerides, HDL, VLDL, glucose, urea, and creatinine levels. The atherosclerotic patients displayed considerable differences in their cardiometabolic, inflammatory, cardiac, and renal biomarkers with many of them changing significantly after catheterization.
