Folic acid and Cancerحلقة نقاشية

Tuesday 5 Jan 2021, 10:00 → 12:00 Asia/Baghdad

college of medicine

Rana Ali (University of baghdad,college of medicine)

• Folate is an essential water-soluble B vitamin found in foods, including dark-green leafy vegetables and legumes. Folic acid is the synthetic form of the vitamin present in supplements and fortified foods, namely grains and cereals. Dietary folate exists in a reduced state with polyglutamate side chains requiring oxidation and hydrolysis for absorption, whereas folic acid exists as the oxidized pteroylmonoglutamate form making it readily bioavailable.
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• Due to its role in one-carbon metabolism, folate has been studied extensively as a possible mechanism for cancer development. Folate as 5-Methyltetrahydrofolate (5-MTHF) and cobalamin are required for the conversion of homocysteine to methionine in the methionine pathway. Methionine is converted to S-adenosylmethionine (SAM). SAM is a chief methyl contributor to many reactions in the body, including DNA and RNA methylation.

 

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folic acis & cancer.pptx