Lymphoma is a group of malignant disorders it starts in B, and T lymphocytes, and Natural killer cells, which are type of the white blood cell, play an essential role in the body's immunological system, these malignant cells collect in the lymph nodes and cause characteristic lymphadenopathy, they frequently have the potential to leak into circulation or invade organs beyond the lymphatic system, the major subdivisions of lymphoma are Hodgkin and Non-Hodgkin lymphoma, lymphoma most commonly affect cervical lymph nodes, and may remain grow and wane for several months, furthermore lymphadenopathy may be the only manifestation of lymphoma.