Varicella-zoster virus (VZV) also known as (human herpesvirus 3) genus Varicella virus, subfamily Alpha herpes virinae is a virus that infects humans and causes Primary infection of chicken pox varicella. After the primary infection, VZV stays in the body (in the sensory nerve ganglia) as a latent infection. Reactivation of latent infection causes herpes zoster (shingles (. Shingles is the latent infection of varicella zoster (herpes virus 3)The rash most commonly occurs in a single stripe around the left or the right side of the body. The rash can also occur on one side of the face. Shingles on the face can affect the eye and cause vision loss. The rash can be more widespread and look similar to a chickenpox rash. This is very rare and usually occurs in people with weakened immune systems