MICRORNA-223 REGULATES NLRP3 AND AIM2 INFLAMMASOMES ACTIVATION AND INFLAMMATORY RESPONSE IN RELATION TO ORAL MANIFESTATIONS OF RHEUMATOID ARTHRITIS
Background: Rheumatoid arthritis is a systemic autoimmune disease characterized by significant inflammation and structural damage to the joints. The field of rheumatoid arthritis epigenetics includes the study of micro ribonucleic acids. The inflammasome is a cellular signaling complex composed of many proteins that detects pathogens and triggers the inflammatory response in both normal and pathological conditions. Absent in melanoma 2 and nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3, are inflammasomes which are widely recognized as the most extensively investigated. Micro ribonucleic acids have a regulatory role in the post-transcriptional regulation of the inflammasomes responsible for the production of pro-inflammatory cytokines interleukin-1Beta and interleukin-18.