The quality of the maxillofacial silicone material plays a major role in the performance of the maxillofacial prosthesis, its durability, and the patient's adaptation to and satisfaction with the prosthesis. Nowadays, the commercially available silicone materials still need some development to meet the physical, mechanical, and biological requirements. This study aims to investigate the most effective percentages of thymol micropowder for retarding Candida albicans (C. albicans) adhesion on the surface of thymol-modified maxillofacial silicone material and its effect on some important physical and mechanical properties of the silicone.