Obesity and periodontitis are two prevalent health challenges that have garnered considerable attention in the field of public health and medicine. Obesity, characterized by excessive body fat accumulation, and periodontitis, a chronic inflammatory disease affecting the supporting structures of the teeth, have both been associated with systemic inflammation and an increased risk of various chronic conditions. Proinflammatory cytokines and adipokines are mainly expressed into oral fluids and may lead to detrimental effects on periodontium, promoting inflammation, tissue destruction, and bone loss in the context of periodontal diseases